The year 2020 brought us an event that has affected the entire world, the SARS-CoV-2 pandemic arrived and literally changed everyone’s life. Coronavirus disease 2019 (COVID-19) is an ongoing viral pandemic that has spread very rapidly globally. The causative agent of this infection has been identified as a new RNA virus, from the coronavirus family, called severe acute respiratory syndrome coronavirus 2, SARS-CoV-2. Faced with this health emergency that took us by surprise, we had to look at another aspect of mouthwashes: their antiviral capacity. Until now, we were mainly concerned with the anti-bacterial aspect, but in recent months, concepts such as «lowering the viral load» have become very common in the dental practice. The international scientific community, having noticed and found that this virus enters through the mouth and nearby structures such as the nose, began to study how mouthwashes can help to reduce the viral load or amount of SARS-CoV-2 in the oral-pharyngeal environment. The complexity of this situation is that there were very few studies on the effectiveness of different mouthwashes against viruses, the few that existed were on SARS-CoV-1 or on other double-enveloped viruses such as influenza, herpes simplex or novavirus, these studies allowed extrapolating results and expressing that mouthwashes are necessary to help combat the virus causing the terrible pandemic we are currently experiencing. SARS-CoV-2 is an enveloped virus characterised by an outer lipid membrane derived from the host cell from which it emerges. While this virus is very sensitive to agents that alter lipid membranes, little research has been done on the potential of mouthwashes to prevent transmission of this deadly disease.